Trifexis - Chewable Heartworm Prevention and Flea Treatment for Dogs
Comfortis chewable tablets kill fleas and are indicated for the prevention and treatment of flea infestations (Ctenocephalides felis) on dogs for one month.
A wide margin of safety of advantus™ soft chewable tablets was demonstrated with daily administration for 6 months at approximately 1, 3 and 5 times the recommend dose. No adverse events were reported which supports the extended daily use of the soft chewable tablets for dogs. Daily use of the soft chewable tablet will eliminate flea infestations on the dog before they start laying eggs. The presence of dogs in an infested environment will provide constant stimulation for the pre-adult stages of the fleas to emerge and infest the dog, but newly infesting fleas will be eliminated quickly by treatment of the dog with advantus™ soft chewable tablets. Studies have shown that in heavily contaminated environments it takes up to 2 months (60 days) to clean the environments of cycling flea populations .
Development of advantus™ soft chewable tablets for the treatment of adult flea infestations of dogs was described. The characteristics of the product include convenience of administering imidacloprid as a soft chewable tablet that is rapidly absorbed within approximately 1 hour and eliminated rapidly as well, with a half-life of approximately 2 hours. These characteristics translate to rapid start to kill activity of 1 hour and speed of flea kill at 4 hours. Substantial evidence of efficacy was demonstrated with 96 % efficacy as early as 4 hours. The safety profile was excellent with no test substance related adverse events reported following 1, 3 and 5 times the dose administered daily for 6 months. Excellent safety and substantial efficacy was also demonstrated in a field efficacy study in client owned dogs.
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Studies reported here were conducted to evaluate the safety and effectiveness of advantus™ (imidacloprid) soft chewable tablets for the treatment of flea (Ctenocephalides felis) infestations on dogs and puppies 10 weeks of age or older and weighing 4 pounds or greater.This manuscript describes five studies conducted for the development of advantus™ soft chewable tablets containing imidacloprid for treatment of flea infestations on dogs and puppies 10 weeks of age or older and weighing 4 lb (1.8 kg) or greater. The advantus™ soft chewable tablets are available in two sizes; 7.5 mg imidacloprid for dogs weighing 4 to 22 lb (1.8–10 kg) in weight and 37.5 mg imidacloprid for dogs weighing 23 to 110 lb (10–50 kg) in weight. Studies were conducted to establish the pharmacokinetic characteristics, for substantial evidence of activity against fleas (efficacy and speed of kill), for confirmation of safety in target species, and to evaluate field experience regarding safety and efficacy of the product as used by pet owners.Imidacloprid administered orally as a soft chewable tablet for the treatment of fleas on dogs was safe and highly effective with a rapid knockdown effect and rapid elimination.Find out how Comfortis for dogs works to prevent fleas from infesting and harming your pet. The once-a-month chewable tablet gets to work in just minutes and protects dogs from fleas for 30 days.
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