Briefly, here are the main benefits of using DNA test kits for dogs:
Have you had your dog’s DNA tested, or yours? What was your experience, and were there any surprises? Let us know in the comments!
S Locus (DNA marker – MITF reference: Schmutz S, TG Berryere and DL Dreger. MITF and white spotting in dogs: a population study. Journal of Heredity 2009, 100(Supl 1):S66-S74.) This allele is associated with Piebald, Parti, Landseer or Random White Spotting among several breeds where these patterns are observed. The inheritance and expression can vary depending on the breed. For example, the gene is most often recessive in nature, however in some breeds such as Collie, Great Dane, Italian Greyhound, Shetland Sheepdog, Boxer, and Bull Terrier, an animal having 1 copy of the piebald allele can exhibit some limited piebald expression.
H locus (DNA marker tested – PSMB7:c.146T>G) Harlequin Merle-colored Great Danes have dark spots on a diluted/grey background. The Harlequin gene causes a white background and the spots increase in size. Dogs that are not merle, cannot express the Harlequin color/pattern. Breeding two dogs that both have a copy of the H locus “NH” is not recommended. A dog with two copies of Harlequin has not been observed and It is presumed to be lethal in utero. This gene is inherited as a dominant trait.
All ten DNA-tested dogs have since been adopted.
The Hidden Benefits of DNA Testing for Dogs | petMD
The view that dogs came along at about the same time as human beings settled down is so widespread and so often repeated in standard texts that it is more than a bit surprising to find genetic evidence flatly contradicting it. The evidence comes from a study by Robert Wayne, an evolutionary biologist at the University of California at Los Angeles, who has applied the modern tools of genetic fingerprinting to dogs, coyotes, wolves, and jackals. He and his colleagues collected blood, tissue, or hair samples from 140 dogs of sixty-seven breeds and 162 wolves from three continents. To gauge how closely related these various canines were and when they might have diverged from a common ancestor, the scientists measured differences in their mitochondrial DNA. Mitochondria are like small cells within the cells of animals; they convert stored food into energy with the assistance of oxygen, and they also have the peculiarity -- much cherished by geneticists -- of reproducing asexually, independent of the rest of the cell. The regular DNA of an animal cell derives equally from both parents. Mitochondrial DNA, however, comes entirely from the mitochondrial DNA of the mother. In normal sexual reproduction genetic change from one generation to the next is very rapid, as the parental genes are mixed and remixed in new combinations. Mitochondrial DNA, in contrast, can change only by mutation, which takes place quite slowly -- at a rate of around one or two percent every 100,000 years.Wayne's study also definitively laid to rest an assertion made by both Charles Darwin and Konrad Lorenz -- that more than one wild canid species had to have made an appearance in the dog's recent family tree, given the diversity of physical types and behaviors exhibited across the range of modern dog breeds. In fact, long sequences of dog mitochondrial DNA are similar or identical to those in gray wolves, and analysis of the highly variable markers in the regular DNA of dogs and wolves shows a considerable overlap there as well. Jackals and coyotes, though they can interbreed with dogs and produce fertile offspring, possess quite distinct groups of mitochondrial DNA sequences.